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Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-κB activation

✍ Scribed by Aung, Gyi; Niyonsaba, François; Ushio, Hiroko; Ikeda, Shigaku; Okumura, Ko; Ogawa, Hideoki

Book ID: 119293757
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 510 KB
Category: Article
ISSN: 0923-1811
DOI: 10.1016/j.jdermsci.2011.04.014

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi