Einfluß von Violamycin BI auf den Ablauf der Excisionsreparatur in Escherichia coli K12 nach UV-Bestrahlung
✍ Scribed by Dr. Karin Stöbl; W. F. Fleck; D. Strauss
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 390 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0233-111X
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✦ Synopsis
Abstract
The influence of violamycin B I on the process of excision repair of DNA‐damages after UV‐irradiation has been studied by observing the capacity to rejoin single‐strand breaks introduced in the DNA at the beginning of the repair process. The number of single‐strand breaks remaining unrepaired in the DNA was higher in presence of violamycin B I. Sedimentation analysis of the DNA of unirradiated cells showed in presence of violamycin B I only a small change in the molecular weight
As a possible reason for the lower capacity of the cells to accomplish repair steps following incision in presence of violamycin B I an inhibition of the function of repair enzymes by interaction of the antibiotic with the DNA‐template is discussed.