Einfluß von Insulin auf das Membranpotential bei alimentärem Kaliummangel

✍ Scribed by H.-D. Bolte; B. Lüderitz

• Book ID: 104740703
• Publisher: Springer
• Year: 1968
• Tongue: English
• Weight: 278 KB
• Volume: 301
• Category: Article
• ISSN: 0031-6768
• DOI: 10.1007/bf00363772

✦ Synopsis

Influence el Insulin on Membrane Potentials in Potassium Deficiency

Measurements in Isolated Eat Diaphragm Summary. In 102 single muscle cells of 7 rats with alimentary potassium depletion we found under influence of insulin (0.1 I.U./ml) a depolarisation of ll.2mV, i.e. from --94.6 (s = 4-6.4)mV (100 cells) to --83.4 (s = =J= 6.8)mV (p < 0.001). The potassium concentration in the incubation medium was 4.7 (s -----4-0.29) mequ/l. --In addition we measured under influence of insulin (0.1 I.U./ml) an intraeellular potassium concentration of 130mval/l~oizR, which is probably higher than in potassium deficient animals without insulin (p < 0.05). These findings suggest that insulin produces a netto potassium influx in potassium deficient animals, which could explain the depolarisation.