Eine vereinfachte Methode zur funktionellen Hepatektomie

✍ Scribed by W. Poser; R. Jahns

• Publisher: Springer
• Year: 1967
• Tongue: English
• Weight: 231 KB
• Volume: 297
• Category: Article
• ISSN: 0031-6768
• DOI: 10.1007/bf00362712

✦ Synopsis

A description of a simplified method for functional hepatectomy in the rat is given. The liver is excluded from circulation by ligation of the afferent vessels. The blood of the portal vein is transferred to the jugular vein by an implanted polyethylene tube. l~ats thus deprived of their liver survive for several hours. They are unable to maintain normal blood glucose levels, they fail to eliminate pentobarbital or to detoxicate ammonia. As the animals do still show a hypoglycemic response to tolbutamide functional hepatectomy did apparently not impair insulin release from the pancreatic islets. This indicates that the organs drained by the portal vein are not severely damaged by the operational procedure.