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Eine Synthese 1-substituierter 5-Cyanuracile

✍ Scribed by Wolfbeis, Otto S.

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
214 KB
Volume
1982
Category
Article
ISSN
0947-3440

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✦ Synopsis

Synthesis of 1‐Substituted 5‐Cyanouracils

Condensation of (cyanoacetyl)urea (1) with aniline and trimethoxymethane affords (3‐anilino‐2‐cyanoacryloyl)urea (2a), which thermally cyclizes to form strongly fluorescent 5‐cyano‐1‐phenyluracil (3a). By using 2‐aminopyridine or trimethoxyethane, other uracils (3b, c) are obtained. 3a–c are hydrolyzed to yield the carboxamides 4a–c. UV and fluorescence data are given for the compounds 3 and 4.

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