Ein statistisches Verfahren zur Ermittlung der Leistungs-Korrelation antibioticabildender Mikroorganismen im Labor- und Technikumsmaßstab
✍ Scribed by Dr. M. Horn; E. J. Bormann; M. Harnisch
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 437 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0233-111X
No coin nor oath required. For personal study only.
✦ Synopsis
The antibiotic yields of industrial selectants must be checked a t several steps of cultivation. Here the question arises whet,her t,he activities a t the different levels of cultivation are correlated. The common coefficient of correlat,ion cannot be used because repeated determinations of the yield at one selectant result in different values. I n order to have only one fixed value per selectant we define the mean value around which the observed values are varying. Buth these mean values cannot be observed. Thus, an a,deqnate method of correlation similar to t,hat in GUIARD and HER-RENDORFER (1977) was used. The method is demonstrated in two examples: With selectants of Streptomyces noursei for streptot,hricin tit,ers in 20 ml-and 20 I-cultures as well as with selectants of Penicillium chrysogenum for potency indices in surface cultures and penicillin titers in 50 ml submerged cultures, respectively. I n bot,h cases the cocfficients of correlation were above 0.7.