✦ LIBER ✦
Ein neuer Zugang zum tetracyclischen Grundgerüst des Cyclohepta (def)fluorens
✍ Scribed by Richard Neidlein; Walter Kramer
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- German
- Weight
- 272 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
A New Synthetic Way to the Tetracyclic Skeleton of Cyclohepta (def)fluorene
The synthesis of 2‐Methyl‐4, 5, 6, 8, 9, 10‐hexahydrocyclohepta (def)fluorene 2 is described starting with the reduction of the ketone 3 by a (1:1)‐mixture of LiAlH~4~/AlCl~3~ to the hydrocarbon 4. After metallation with butyllithium 4 was allowed to react with bromoacetic acid to yield 5. The cyclization of this compound was performed with p‐toluenesulfonic acid to give the tetracyclic ketone 6 which was converted to the tetracyclic hydrocarbon 2 by reduction with LiAlH~4~/AlCl~3~.