Egg and sperm recognition systems during fertilization
β Scribed by Noritaka Hirohashi; Noriko Kamei; Hideo Kubo; Hitoshi Sawada; Midori Matsumoto; Motonori Hoshi
- Book ID
- 118703587
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 214 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0012-1592
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Mammalian eggs are surrounded by two egg coats: the cumulus oophorus and the zona pellucida, which is an extracellular matrix composed of sulfated glycoproteins. The first association of the spermatozoon with the zona pellucida occurs between the zona glycoprotein, ZP3 and sperm receptors, located a
## Abstract For sperm to fertilize eggs, they must first bind to the thick zona pellucida (ZP) that surrounds the plasma membrane of all unfertilized mammalian eggs. An extensive literature suggests that mouse sperm recognize and bind to a specific ZP glycoprotein called mZP3. However, the role of