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EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity

✍ Scribed by Donnini, S; Finetti, F; Terzuoli, E; Giachetti, A; Iñiguez, M A; Hanaka, H; Fresno, M; Rådmark, O; Ziche, M


Book ID
118255157
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
591 KB
Volume
31
Category
Article
ISSN
0950-9232

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Expression of microsomal prostaglandin E
✍ Bastiaan P. van Rees; Anna Sivula; Staffan Thorén; Hiroshi Yokozaki; Per-Johan J 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 317 KB

Gastrointestinal carcinomas synthesize elevated levels of prostaglandin E(2) (PGE(2)), which has been mechanistically linked to carcinogenesis. Recently, microsomal prostaglandin E synthase-1 (mPGES-1) was cloned, which seems to be inducible and linked to cyclooxygenase-2 (Cox-2) in the biosynthesis