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EGFR signaling pathway negatively regulates PSA expression and secretion via the PI3K-Akt pathway in LNCaP prostate cancer cells

✍ Scribed by Tomoaki Hakariya; Yohei Shida; Hideki Sakai; Hiroshi Kanetake; Tsukasa Igawa


Book ID
116292300
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
854 KB
Volume
342
Category
Article
ISSN
0006-291X

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✍ Dae-Hee Lee; Miroslaw-Jerzy Szczepanski; Yong J. Lee πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 413 KB

## Abstract We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb __Magnolia officinalis__, induced apoptotic cell death in a dose‐ and time‐dependent manner. A sustained inhibition of the major su