EGFR family: Structure physiology signalling and therapeutic targets †† The EGFR family members regulate the production, survival, movement, and shape of many embryonic and adult cell types. Signalling from three of the family members EGFR, erbB3 and erbB4) are regulated by ligand dependent oligomerization and fourth, erbB2, by oligomerization with ligated forms of the other family members. Three of the family members (EGFR, erbB2 and erbB4) signal via activated tyrosine kinase scaffolds, the fourth, erbB3, by ligand induced oligomerization and activation of the other family members.