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EGF-stimulated migration in ovarian cancer cells is associated with decreased internalization, increased surface expression, and increased shedding of the urokinase plasminogen activator receptor

✍ Scribed by Emir Henic; Michael Sixt; Stefan Hansson; Gunilla Høyer-Hansen; Bertil Casslén

Book ID
113960290
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
396 KB
Volume
101
Category
Article
ISSN
0090-8258

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The plasminogen activating system is involved in tumor growth and metastasis by degradation of extracellular matrix, and modulation of cell adhesion and migration. Benign and well-differentiated malignant ovarian tumors present as cystic lesions with preserved glandular morphology, whereas poorly di