EGF receptor expression in primary laryngeal cancer: Correlation with clinico-pathological features and prognostic significance

✍ Scribed by Maurizio Maurizi; Giovanni Scambia; Pierluigi Benedetti Panici; Gabriella Ferrandina; Giovanni Almadori; Gaetano Paludetti; Rosa De Vincenzo; Mariagrazia Distefano; Domenico Brinchi; Gabriella Cadoni; Salvatore Mancuso

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: French
• Weight: 475 KB
• Volume: 52
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910520605

✦ Synopsis

Epidermal-growth-factor-receptor(EGFR) expression was evaluated in 103 primary laryngeal tumors and in 42 normal laryngeal tissue specimens. Significantly higher EGFR levels were found in cancer specimens than in normal mucosa (p = 0.0053). EGFR expression did not correlate with age, tumor localization, T classification, cervical-lymph-node involvement or type of surgery, whereas it was higher in poorly differentiated tumors (G3) than in well/moderately differentiated (G 1 4 2 ) tumors (p < 0.05). Follow-up data were available for 74 patients. When EGFR status and the most important clinico-pathological characteristics were submitted to univariate analysis, tumor localization, type of surgery and EGFR status were found to be significantly correlated with disease-free survival. The 24-month disease-free survival rate was 58% for EGFR+ cancer patients and 82% for EGFR-ones. With multivariate analysis, only EGFR status and tumor localization were identified as significant independent prognostic parameters. Data reported here suggest that high EGFR levels may identify a sub-set of laryngeal-cancer patients with a particularly unfavorable prognosis.