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EGF in breast cyst fluid: Relationships with intracystic androgens, estradiol and progesterone

✍ Scribed by F. Boccardo; R. Torrisi; S. Zanardi; G. Valenti; F. Pensa; V. De Franchis; A. Barreca; P. Ferraro; F. Minuto

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
459 KB
Volume
47
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The relationship between intracystic levels of epidermal growth factor (EGF) and those of dehydroepiandrosterone sulphate (DHEA‐S), Δ‐4‐androstenedione (Δ‐4‐A), 17‐β‐estradiol (17‐β‐E) and progesterone (PROG) have been studied in 77 breast cyst fluid (BCF) samples. EGF and all tested hormones appeared to be inversely correlated with the intracystic Na^+^/K^+^ ratio (p < 0.001). Consequently, when the BCFs were subdivided according to the Na^+^/K^+^ ratio, significantly higher levels of EGF, DHEA‐S, Δ‐4‐A, 17‐β‐E and PROG were found in Na^+^/K^+^ < 3 BCFs compared with Na^+^/K^+^ > 3 BCFs (p< 0.001 in all cases). Strong direct relationships were found among all steroid hormones when they were correlated to one another (p< 0.001). Intracystic EGF concentration was directly and significantly correlated with each tested hormone (p< 0.001). However, the relationship between EGF and steroid hormones appeared to be different in the 2 BCF types (Na^+^/K^+^ < 3 or >3).

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