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EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2

✍ Scribed by Indu R. Chandrashekaran; Christopher G. Adda; Christopher A. MacRaild; Robin F. Anders; Raymond S. Norton


Book ID
116178893
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
947 KB
Volume
513
Category
Article
ISSN
0003-9861

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## Abstract Merozoite surface protein 2 (MSP2) from the human malaria parasite __Plasmodium falciparum__ is expressed as a GPI‐anchored protein on the merozoite surface. It has been implicated in the process of erythrocyte invasion and is a leading vaccine candidate. MSP2 is an intrinsically unstru

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## Abstract Merozoite surface protein 2 (MSP2) is a GPI‐anchored protein on the surface of the merozoite stage of the malaria parasite Plasmodium falciparum. It is largely disordered in solution, but has a propensity to form amyloid‐like fibrils under physiological conditions. The N‐terminal conser