Efforts Toward the Direct Experimental C
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Dan Groff; Megan C. Thielges; Susan Cellitti; Peter G. Schultz; Floyd E. Romesbe
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Article
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2009
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John Wiley and Sons
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English
⚖ 309 KB
## Abstract **State secrets**: Site‐specific deuteration and FTIR studies reveal that Tyr100 in dihydrofolate reductase plays an important role in catalysis, with a strong electrostatic coupling occuring between Tyr100 and the charge that develops in the hydride‐transfer transition state (see pictu