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Efficient transformation of small hepatocytes into insulin-expressing cells by forced expression of Pdx1

✍ Scribed by Kawasaki, Hiroyuki ;Mizuguchi, Toru ;Oshima, Hideki ;Nobuoka, Takayuki ;Shibata, Toshihito ;Kaji, Shinsuke ;Kokai, Yasuo ;Katsuramaki, Tadashi ;Mitaka, Toshihiro ;Hirata, Koichi

Publisher: Springer
Year: 2008
Tongue: English
Weight: 408 KB
Volume: 15
Category: Article
ISSN: 0944-1166
DOI: 10.1007/s00534-007-1318-2

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## Abstract The conversion of expandable liver progenitor cells into pancreatic beta cells would provide a renewable cell source for diabetes cell therapy. Previously, we reported the establishment of liver epithelial progenitor cells (LEPCs). In this work, LEPCs were modified into EGFP/Pdx‐1 LEPCs