✦ LIBER ✦
Efficient synthesis of the κ-opioid receptor agonist CJ-15,161: four stereospecific inversions at a single aziridinium stereogenic center
✍ Scribed by Michel Couturier; John L. Tucker; Brian M. Andresen; Keith M. DeVries; Brian C. Vanderplas; Fumitaka Ito
- Book ID
- 104360041
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 202 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0957-4166
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✦ Synopsis
An efficient four-step sequence has been developed for the synthesis of the k-opioid receptor agonist CJ-15,161. The process features four consecutive regioselective and stereospecific inversions at a single aziridinium stereogenic center, which leads to overall retention of stereochemistry, in a single operation. The chemistry is straightforward, practical and amenable to large-scale synthesis.