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Efficient Synthesis of (S)-4(5)-[1-(2,3-Dimethylphenyl) ethyl]imidazole tartrate, the Potent α 2 Adrenoceptor Agonist Dexmedetomidine

✍ Scribed by Cordi, Alex A.; Persigand, Thierry; Lecouvé, Jean-Pierre


Book ID
120434852
Publisher
Taylor and Francis Group
Year
1996
Tongue
English
Weight
319 KB
Volume
26
Category
Article
ISSN
0039-7911

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✍ Aihua Wang; Yan Zhang; Songfeng Lu; William V. Murray; Gee-Hong Kuo 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 140 KB

## Abstract magnified image An efficient and scalable synthesis of the potent CETP inhibitor, (2__R__,α__S__)‐3,4‐dihydro‐2‐[3‐(1,1,2,2‐tetrafluoroethoxy)phenyl]‐5‐[3‐(trifluoromethoxy)phenyl]‐α‐(trifluoromethyl)‐1(2__H__)‐quinolineethanol 1, is described. One of the important intermediates, tetrah