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Efficient Synthesis of Resin-Bound α-TMSdiazoketones and Their Use in Solid-Phase Organic Synthesis

✍ Scribed by Yasuyoshi Iso; Hirohisa Shindo; Hiroshi Hamana

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
183 KB
Volume
56
Category
Article
ISSN
0040-4020

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✦ Synopsis

AbstractÐa-TMSdiazoketones on a solid support could be simply and ef®ciently prepared by reaction of the corresponding resin-bound acid chlorides with excess TMSdiazomethane, without any bases. These a-TMSdiazoketones were used via carbenes or carbenoids for a variety of solid-phase reactions. These useful solid-phase reactions allow ef®cient construction of diverse compound libraries by use of combinatorial chemistry, due to the high reactivity and wide applications of the carbenes or carbenoids.

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