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Efficient synthesis of novel benzo[b][1,8]naphthyridin-4(1H)-ones and pyrido[2,3-b]quinoxalin-4(1H)-ones from alkynones and primary amines

✍ Scribed by Iaroshenko, Viktor O.; Zahid, Muhammad; Mkrtchyan, Satenik; Gevorgyan, Ashot; Altenburger, Kai; Knepper, Ingo; Villinger, Alexander; Sosnovskikh, Vyacheslav Ya.; Langer, Peter


Book ID
120528683
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
479 KB
Volume
69
Category
Article
ISSN
0040-4020

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190, CH-8057 Zurich (26. VIII. 93) Condensation of 3,4-dihydro-6,7-dimethoxyisoquinoline (4) with 4-methylnicotinoyl chloride (12) in refluxing pyridine gives 5,6,13,13a-tetrahydro-2,3-dimethoxy-8~-isoquino[2,l-b][2,7]naphthyridin-8-one (Il), along with some of its 13,13a-didehydro derivative 7. A s