Efficient Synthesis of Glycoporphyrins by Microwave-Mediated “Click” Reactions

✍ Scribed by Oliver B. Locos; Claudia C. Heindl; Ariadna Corral; Mathias O. Senge; Eoin M. Scanlan

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 112 KB
• Volume: 2010
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200901292

✦ Synopsis

Abstract

The Cu^I^‐catalysed Huisgen cycloaddition “click” reaction has been applied to the synthesis of a range of triazole‐linked glycoporphyrins. The “click” reaction under microwave‐heating conditions has been shown to provide a general and robust methodology for the synthesis of mono‐, di‐, tri‐ and tetra‐modified glycoporphyrins. A sequential “double‐click” process was employed to access a new class of bis‐modified 5,10‐diglycoporphyrins displaying heterogeneous carbohydrates.