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Efficient Synthesis of Ganglioside GM2 for Use in Cancer Vaccines

✍ Scribed by Julio C. Castro-Palomino; Dr. Gerd Ritter; Sheila R. Fortunato; Stefan Reinhardt; Dr. Lloyd J. Old; Prof. Dr. Richard R. Schmidt

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
590 KB
Volume
36
Category
Article
ISSN
0044-8249

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## Abstract __Two metabolically engineered__ Escherichia coli __strains have been constructed to produce the carbohydrate moieties of gangliosides GM2 (GalNAc__Ξ²__‐4(NeuAc__Ξ±__‐3)Gal__Ξ²__‐4Glc; Gal=galactose, Glc=glucose, Ac=acetyl) and GM1 (Gal__Ξ²__‐3GalNAc__Ξ²__‐4(NeuAc__Ξ±__‐3)Gal__Ξ²__‐4Glc. The G