Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes: Application to the synthesis of escitalopram
β Scribed by Wang, Peng; Zhang, Rui; Cai, Jin; Chen, Jun-Qing; Ji, Min
- Book ID
- 121672946
- Publisher
- Chinese Electronic Periodical Services
- Year
- 2014
- Tongue
- English
- Weight
- 706 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1001-8417
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Phenylaziridine 1 in the presence of an appropriate Lewis acid reacts as a 1,3-dipole. The cyclocondensation of 1 with DHP in the presence of BF3 -Et20 produced the azaoxa[3.2.0] cycloadducts 4a-4b. The reactivity of the corresponding N-tosyliminium ions was explored.
A synthetic route to 1-(2,6-dihydroxyphenyl)phthalan natural products is described. It is typified by the synthesis of permethyl and monomethyl ethers (21 and 22) of pestacin (1), a 1,3-dihydroisobenzofuran natural product. The key step is hydrodeoxygenation of the corresponding isobenzofuranone 19