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Efficient synthesis of enantiomerically pure thioester precursors of [11C]McN-5652 from racemic McN-5652

✍ Scribed by J. Zessin; P. Gucker; S. M. Ametamey; J. Steinbach; P. Brust; F. X. Vollenweider; B. Johannsen; P. A. Schubiger

Publisher: John Wiley and Sons
Year: 1999
Tongue: French
Weight: 275 KB
Volume: 42
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(19991230)42:13<1301::aid-jlcr298>3.0.co;2-2

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## Abstract The highly potent serotonin (5‐HT) uptake blocker, McN‐5652‐Z (__trans__‐1,2,3,5,6,10b ‐ hexahydro ‐ 6 ‐ [4 ‐ (methylthio)phenyl] pyrrolo ‐ [2,1‐a]‐isoquinoline) was labeled with ^11^C for studying serotonin uptake sites using positron emission tomography (PET). [^11^C]McN‐5652‐Z was sy