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Efficient Synthesis of d - erythro -Sphingosine and d - e rythro -Azidosphingosine from d - r ibo -Phytosphingosine via a Cyclic Sulfate Intermediate

โœ Scribed by Kim, Sanghee; Lee, Sukjin; Lee, Taeho; Ko, Hyojin; Kim, Deukjoon


Book ID
118164541
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
80 KB
Volume
71
Category
Article
ISSN
0022-3263

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A simple and low cost synthesis of d-ery
โœ Richard J.B.H.N. van den Berg; Cornelis G.N. Korevaar; Gijsbert A. van der Marel ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 210 KB

D-erythro-Sphingosine (1) and D-erythro -2-azidosphingosine (2) are both prepared from commercially available and cheap D-ribo -phytosphingosine (3) in a yield of 58% and 70%, respectively. A key transformation in the synthesis of D-erythro -sphingosine (1) is the palladium catalyzed regiospecific r