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Efficient Synthesis of Conformationally Constrained Peptidomimetics Containing 2-Oxopiperazines 1

✍ Scribed by Pohlmann, Adriana; Schanen, Vincent; Guillaume, Dominique; Quirion, Jean-Charles; Husson, Henri-Philippe


Book ID
121810372
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
298 KB
Volume
62
Category
Article
ISSN
0022-3263

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## Abstract Sulfonyl peptides containing a serine or threonine residue undergo cyclization with bis(succinimidyl) carbonate (DSC) and diisopropylethylamine (DIPEA) to give peptides with a 2‐oxo‐1,3‐oxazolidine‐4‐carboxylate (Oxd) group, either in solution or in the solid phase. The position of the