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Efficient synthesis of carbapenems via the oxalimide cyclization. Manipulation of protecting groups at the oxalimide stage

✍ Scribed by Steven A King; Brenda Pipik; Andrew S Thompson; Ann DeCamp; Thomas R Verhoeven


Book ID
103411063
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
323 KB
Volume
36
Category
Article
ISSN
0040-4039

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A stereoselective method for introducing a C2-unit at the 1 or-and 1 I~-postions of D-glucose and D-mannose, respectively, via a radical cyclization reaction with vinylsilyl group as a temporary connecting tether, was developed. The radical cyclization of D-glucose substrates was effectively facilit