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Efficient synthesis of a series of novel fructose-based 3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazole derivatives and studies of the reaction mechanism

✍ Scribed by Dong Han; Xiang-Bao Meng; Lin-Na Wang; Hong Liu; Yun Yao; Zhuo Wang; Zhen-Jun Yang; Zhen-Min Liu; Zhong-Jun Li

Book ID: 108284427
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 714 KB
Volume: 20
Category: Article
ISSN: 0957-4166
DOI: 10.1016/j.tetasy.2008.12.033

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## Abstract 3‐Benzylindole‐2‐carbohydrazides (4) on reaction with triethylorthoformate in a polar solvent like DMF yielded only 10‐benzyl‐1,2‐dihydro‐1‐oxo‐1,2,4‐triazino[4,5‐__a__]indoles (5) while (4) on reaction with triethylorthoacetate in DMF yielded both 10‐benzyl‐4‐methyl‐1,2‐dihydro‐1‐oxo‐1