Efficient synthesis of 6-aryl-2-chloronicotinic acids via pd catalyzed regioselective suzuki coupling of 2,6-dichloronicotinic acid

✍ Scribed by Mingliang Ma; Chengwei Li; Xiaoyan Li; Ke Wen; Yahu A. Liu

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 123 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450646

✦ Synopsis

Abstract

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A regioselective Suzuki coupling of 2,6‐dichloronicotinic acid with aryl boronic acids to synthesize 6‐aryl‐2‐chloronicotinic acids is described. Regioselectivity was achieved in aqueous dioxane using the routinely used catalyst Pd(PPh~3~)~4~.