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Efficient Synthesis of 2,4-Disubstituted Thiazoles Under Grinding

✍ Scribed by Heravi, Majid M.; Poormohammad, Nargess; Beheshtiha, Yahia S.; Baghernejad, Bita


Book ID
118018699
Publisher
Taylor and Francis Group
Year
2011
Tongue
English
Weight
114 KB
Volume
41
Category
Article
ISSN
0039-7911

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3-Iodobenzoic acid was loaded on Rink amide resin. Pd(0) coupling reaction with tributyl(1-ethoxyvinyl)tin followed by bromination using NBS gave an a-bromoketone bound to a solid support. Condensation of thioamide or thiourea, followed by TFA cleavage from the resin, gave 2,4-disubstituted thiazole