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Efficient synthesis of 2,3-unsaturated sulfonamidoglycosides by Amberlyst 15

✍ Scribed by Carlos A. Témpera; Pedro A. Colinas; Rodolfo D. Bravo


Book ID
104098101
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
247 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis


Sulfonamidoglycosylation of D-glycals in the presence of Amberlyst 15 proceeded effectively to afford the sulfonamidoglycosides in good to high yields with minimal workup and short reaction times. Two N-glycosyl sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range.


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