Efficient synthesis of 2-trihalomethyl-5-cyanopyridines
✍ Scribed by Jason WB Cooke; Mark J Coleman; Darren M Caine; Kevin P Jenkins
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 120 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Efficient and practicable routes to 2-trifluoromethyl-5-cyanopyridine, 2-bromodifluoromethyl-5-cyanopyridine and 2-chlorodifluoromethyl-5-cyanopyridine have been developed.
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## Abstract The synthesis of a novel series of twelve 4‐(trihalomethyl)dipyrimidin‐2‐ylamines, from the cyclo‐condensation reaction of 4‐(trichloromethyl)‐2‐guanidinopyrimidine, with β‐alkoxyvinyl trihalomethyl ketones, of general formula: X~3~C‐C(O)‐C(R^2^)=C(R^1^)‐OR, where: X = F, Cl; R = Me, Et
## Abstract For Abstract see ChemInform Abstract in Full Text.