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Efficient synthesis and spectral determination of 11-[(o- m- and p-substituted)-phenyl]-8-chloro-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones

✍ Scribed by Eduardo Cortés Cortéas; Miryan Adaya Baños; Olivia García-Mellado De Cortés

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
120 KB
Volume
41
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A new synthesis to obtain eleven novel derivatives of 11‐[(o‐ m‐ and p‐substituted)‐phenyl]‐8‐chloro‐3,3‐dimethyl‐2,3,4,5,10,11‐hexahydro‐1__H__‐dibenzo[b,e][1,4]diazepin‐1‐ones with possible pharmacological activity in the central nervous system in two efficient steps has been developed. The final products were obtained by condensation and cyclization between 3‐[4‐chloro‐1,2‐phenylenediamine]‐5,5‐dimethyl‐2‐cyclohexenone with (o‐ m‐ and p‐substituted)benzaldehyde. The structure of all products was corroborated by ir, ^1^H‐nmr, ^13^C‐nmr and high resolution in ms.

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