Efficient Syntheses of (α-Fluoropropargyl)phosphonate Esters
✍ Scribed by Benayoud, Farid; deMendonca, Daniel J.; Digits, Cheryl A.; Moniz, George A.; Sanders, Tanya C.; Hammond, Gerald B.
- Book ID
- 124086896
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 179 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
The efficient preparation of a-fluoro-~,y-alkenylphosphonate 3, via catalytic hydrogenation of (a-fluoropropargyl)phosphonate ester I, is described. Conjugated fluoroenynes 4 have been synthesized using a modified Homer Wadsworth Emmons (HWE) olefmstion of aldehydes or ketones and I in relatively go
Absrracr : Dihpropyl ( macapomethyl) pbosphonace was easily prepad by the reduction of S-merliyl phosphono-ditbioestawith~Umborohydride,beacedundafluXofacetonieile.'Ibephosphonatccabsnmn . g-from eg s-ally1 St&i& denvent a [3Jl sigmatropic shin and ted to diisopmpyl (atlyt mercapto methyl)
Synthetic precursors of amino phosphonic acids are aziridinyl phosphonates. These compounds can be prepared through a reaction of phosphonates 2a-e with NsONHCO 2 Et and inorganic bases involving addition of an (ethoxycarbonyl)amino group onto the double bond, via a new and easy procedure.