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Efficient Syntheses of 2-(2,6-Dichloro-4-trifluoromethyl-phenyl)tetrahydrocyclopenta, Tetrahydrothiopyrano, Hexahydrocycloheptapyrazoles and Tetrahydroindazoles.

โœ Scribed by Sanath K. Meegalla; Dario Doller; Ruiping Liu; Deyou Sha; Richard M. Soll; Dale S. Dhanoa


Book ID
101933876
Publisher
John Wiley and Sons
Year
2003
Weight
114 KB
Volume
34
Category
Article
ISSN
0931-7597

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Efficient syntheses of 2-(2,6-dichloro-4
โœ Sanath K. Meegalla; Dario Doller; Ruiping Liu; Deyou Sha; Richard M. Soll; Dale ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 259 KB

Two methods are described for the regiospecific synthesis of 3,4-fused-cycloalkyl-1-arylpyrazoles; the key step is the reaction between aryl hydrazines and cyclic a-(dimethoxymethyl)ketones. The latter are obtained by BF 3 -promoted alkylation of ketones with trimethylorthoformate.