Efficient stereoselective synthesis of dolastatin 10, an antineoplastic peptide from a sea hare

✍ Scribed by Yasumasa Hamada; Kyoko Hayashi; Takayuki Shioiri

• Book ID: 104225121
• Publisher: Elsevier Science
• Year: 1991
• Tongue: French
• Weight: 265 KB
• Volume: 32
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)92123-3

✦ Synopsis

The stereoselective and efficient synthetic route to dolastatm 10, an antmeoplastx peptide from a sea hare, has been developed. Dolaproine, one of the unusual constituents, was prepared in a highly stereoselective manner by the Evans a/do/ methodology.