A versatile method for the solid phase synthesis of oxazolidin-2-ones is described. A resin bound phenolic group was treated with (Β±)-epichlorohydrin followed by opening of the epoxide ring with sodium azide. The resulting 1-azido-3-aryloxypropan-2-ol was treated with p-nitrophenylchloroformate and
Efficient solid phase synthesis of 3,5-disubstituted hydantoins
β Scribed by Adel Nefzi; John M. Ostresh; Marc Giulianotti; Richard A. Houghten
- Book ID
- 108387117
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 170 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
An efficient and direct conversion of Fmoc-protected dipeptides to hydantoins in the solid phase is described. This methodology uses MeSiCI3 in the presence of Et3N to cleave Fmoc-protected amines directly to their isocyanates. Internal cyclization of the amide on the isocyanate follows to produce t
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