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Efficient Semisynthesis of a Tetraphosphorylated Analogue of the Type I TGFβ Receptor

✍ Scribed by Flavell, Robert R.; Huse, Morgan; Goger, Mike; Trester-Zedlitz, Michelle; Kuriyan, John; Muir, Tom W.

Book ID
127137860
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
98 KB
Volume
4
Category
Article
ISSN
1523-7060

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Transforming growth factor-beta (TGF-beta) signaling is initiated following heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Both receptors are required for TGF-beta responsiveness. In the present study, we characterized the actions of TGF-b