CpG-DNA aided cross-presentation of solu
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Tobias Maurer; Antje Heit; Hubertus Hochrein; Franziska Ampenberger; Meredith O'
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Article
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2002
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John Wiley and Sons
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English
โ 203 KB
๐ 2 views
For cross-presentation immature dendritic cells (DC) require enhanced antigen (Ag) uptake and a maturation signal to prime for MHC class I-restricted CTL responses in vivo. While immunostimulatory CpG-DNA provides, via TLR9, the maturation signal, CpG-DNA linked to Ag augments cellular Ag uptake. In