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Efficient S-alkylation of cysteine in the presence of 1,1,3,3-tetramethylguanidine

✍ Scribed by Marek Włostowski; Sylwia Czarnocka; Piotr Maciejewski

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
266 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of S-alkylated cysteine derivatives was carried out successfully in the presence of 1,1,3,3tetramethylguanidine. Alkylation proceeded in high yields on unprotected amino acids and peptides containing a sulfhydryl group.

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