✦ LIBER ✦
Efficient regioselective aldol condensation of methyl ketones promoted by organoaluminum compounds, and its application to muscone synthesis
✍ Scribed by Jiro Tsuji; Toshiro Yamada; Mitsumasa Kaito; Tdakatsu Mandai
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 245 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Regioselective aldol condensation of 2-octanone and 2-butanone at the methyl side proceeded in high yields using a system of dialkylaluminum phenoxide/tertiary amine. The intramolecular aldol condensation of 2,15hexadecanedione was carried out by the same system, especially di-i-butylaluminum phenoxide/pyridine, to give dehydromuscone in 65% yield. Its hydrogenation afforded muscone (3-methylcyclopentadecanone). 3) is called muscone and a famous naturally occurring fragrant compound. Among numerous synthetic methods for muscone so
3-Methylcyclopentadecanone (