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Efficient reduction of aromatic nitro/azido groups on solid support employing indium: synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones

✍ Scribed by Ahmed Kamal; G.Suresh Kumar Reddy; K.Laxma Reddy


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
122 KB
Volume
42
Category
Article
ISSN
0040-4039

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Facile reduction of aromatic nitro/azido
✍ Ahmed Kamal; K.Laxma Reddy; V. Devaiah; G.Suresh Kumar Reddy πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 355 KB

An efficient and mild method for the reduction of aromatic nitro and azido groups on solid support using Al/NiCl 2 β€’6H 2 O and Al/NH 4 Cl is described. This solid phase reduction technique has been applied towards the synthesis of DNA binding pyrrolo[2,1-c][1,4]benzodiazepine antitumour antibiotics.