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Efficient production of ethyl (R)-2-hydroxy-4-phenylbutyrate using a cost-effective reductase expressed in Pichia pastoris

✍ Scribed by Qian, Xiao-Long; Pan, Jiang; Shen, Nai-Dong; Ju, Xin; Zhang, Jie; Xu, Jian-He

Book ID: 125836687
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 738 KB
Volume: 91
Category: Article
ISSN: 1369-703X
DOI: 10.1016/j.bej.2014.07.008

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Optically pure Ethyl (R)-2-hydroxy-4-phenylbutyrate has been synthesized stereoselectively in 24% overall yield. The recent discovery of potent inhibitors of angiotensin-converting enzyme (ACE) which incorporate the ethyl N-substituted-(S)-2-amino-4-phenylbutyrate moiety as a comnon structural eleme