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Efficient Peptide Coupling Involving Sterically Hindered Amino Acids

✍ Scribed by Katritzky, Alan R.; Todadze, Ekaterina; Angrish, Parul; Draghici, Bogdan


Book ID
127147109
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
201 KB
Volume
72
Category
Article
ISSN
0022-3263

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A highly efficient coupling reagent, 2-bromo-3-ethyl-4-methyl thiazolium tetrafluoroborate (BEMT), was designed, synthesized and successfully applied to the synthesis of oligopeptides containing N-alkyl or oc-C-dialkyl amino acids. Its efficiency was evaluated by HPLC and 'H NMR methods, and demonst