## Abstract Cyclohexenes (IV) are efficiently synthesized via a three‐step sequence.
Efficient oxidation-Wittig olefination-Diels–Alder multicomponent reactions of α-hydroxyketones
✍ Scribed by Geraint H. Harris; Andrew E. Graham
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 534 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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Amine-catalyzed Diels-Alder reactions of a,b-unsaturated ketones with dienophiles have been developed. Either (S)-1-(2-pyrrolidinylmethyl)pyrrolidine or L-proline catalyzed the in situ-generation and reaction of 2-amino-1,3-dienes to provide cyclohexanone derivatives in good yield (up to 87%) in one
## Abstract Here we report on our studies on combinations of amino acids and copper(I) for catalyzing multicomponent reactions (MCRs). We aimed to prepare both diene and dienophiles simultaneously, under very mild and environmentally friendly conditions, thus giving the constituents for a stereocon