Efficient one-pot synthetic approaches for cannabinoid analogues and their application to biologically interesting (−)-hexahydrocannabinol and (+)-hexahydrocannabinol

✍ Scribed by Yong Rok Lee; Likai Xia

• Book ID: 104095231
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 141 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.03.075

✦ Synopsis

This Letter reports new and efficient synthetic approaches for biologically interesting cannabinoid analogues. The key strategies involve ethylenediamine diacetate/triethylamine-catalyzed cyclization. As an application of this methodology, one-step synthesis of biologically active natural (À)-hexahydrocannabinol and its unnatural enantiomer (+)-hexahydrocannabinol was carried out.