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Efficient One-Pot Conversion of 6-Methyl-2-nitroaniline into 1-Alkyloxy-2-alkyl-4-methyl-, 1-Benzyloxy-2-phenyl-4-Methyl-, and 1-Allyloxy-4-methyl-2-vinyl-benzimidazole

✍ Scribed by Gardiner, John M.; Loyns, Colin R.


Book ID
115455448
Publisher
Taylor and Francis Group
Year
1995
Tongue
English
Weight
401 KB
Volume
25
Category
Article
ISSN
0039-7911

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Conversion of 1-methyl-4-phenyl-1,2,3,6-
✍ Wieslaw Gessner; Arnold Brossi; Rong-Sen Shen; Richard R. Fritz; Creed W. Abell 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 German ⚖ 383 KB

## Abstract Monoamine oxidase B metabolizes 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP; **1**) first to 1‐methyl‐4‐phenyl‐2,3‐dihydropyridinium salt (MPDP^+^; **5**), and then to 1‐methyl‐4‐phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5‐methyl analog **6** wa