Efficient magnetic resonance imaging methods for automated quantitation of magnetic resonance parameters from multiple samples

✍ Scribed by Stephen D. Evans; Kevin P. Nott; Ashwini Kshirsagar; Laurance D. Hall

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 387 KB
• Volume: 35
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/(sici)1097-458x(199712)35:13<s76::aid-omr215>3.0.co;2-r

✦ Synopsis

Magnetic resonance imaging methods have been developed which simultaneously measure the bulk magnetic resonance parameters of many samples contained in stacks of multi-well sample plates using either a 2.35 T, 31 cm or a 2 T, 100 cm horizontal bore magnet each with a quadrature "birdcageÏ resonator. Computerized automatic edge detection software detects the position of each well within the Ðrst spin-echo image which can then determine the mean magnetic resonance parameters of the sample in each well. An example is given of the automated quantitation of and values for 2% (w/v) agar gel in four plates each with 30 wells per plate (120 samples in total). T 1

, T 2 M 0 It was found that the maximum number of samples that can be analysed is limited by the homogeneity of the probe Ðeld and the Ðeld of the magnet. The applicability of this technology for future applications is discussed. B 1