Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis

✍ Scribed by Yee, Nathan K.; Farina, Vittorio; Houpis, Ioannis N.; Haddad, Nizar; Frutos, Rogelio P.; Gallou, Fabrice; Wang, Xiao-jun; Wei, Xudong; Simpson, Robert D.; Feng, Xuwu; Fuchs, Victor; Xu, Yibo; Tan, Jonathan; Zhang, Li; Xu, Jinghua; Smith-Keenan, Lana L.; Vitous, Jana; Ridges, Michael D.; Spinelli, Earl M.; Johnson, Michael; Donsbach, Kai; Nicola, Thomas; Brenner, Michael; Winter, Eric; Kreye, Paul; Samstag, Wendelin

• Book ID: 127199416
• Publisher: American Chemical Society
• Year: 2006
• Tongue: English
• Weight: 248 KB
• Volume: 71
• Category: Article
• ISSN: 0022-3263
• DOI: 10.1021/jo060285j